tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate
boc-glycine hydroxysuccinimide ester
CAS: 3392-07-2
Molecular Formula: C11H16N2O6
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Names and Identifiers
| Name | boc-glycine hydroxysuccinimide ester |
| Synonyms | BOC-GLY-OSU Boc-Gly-OSu N-Boc-glycine N-succinimidyl ester boc-glycine hydroxysuccinimide ester N-ALPHA-T-BOC-GLYCINE N-HYDROXYSUCCINIMIDE ESTER 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)glycinate 2,5-Dioxopyrrolidin-1-yl 2-((tert-butoxycarbonyl)aMino)acetate tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate |
| CAS | 3392-07-2 |
| EINECS | 222-230-2 |
| InChI | InChI=1/C11H16N2O6/c1-11(2,3)18-10(17)12-6-9(16)19-13-7(14)4-5-8(13)15/h4-6H2,1-3H3,(H,12,17) |
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Physico-chemical Properties
| Molecular Formula | C11H16N2O6 |
| Molar Mass | 272.25 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Melting Point | 165-167°C |
| Appearance | Powder |
| Color | White |
| BRN | 1549242 |
| pKa | 10.51±0.46(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.514 |
| Use | Uses BOC-glycine-N-hydroxypyrrolidinyl Ester is an amino acid organic substance, which can be used as a pharmaceutical intermediate. |
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10-21 |
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Upstream Downstream Industry
| Downstream Products | BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE |
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Security information
| WGK Germany | 3 |
| F | 3-10-21 |
Last Update：2024-04-10 22:29:15
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Nature
| acidity coefficient (pKa) | 10.51±0.46(Predicted) |
| morphology | Powder |
| color | White |
| sensitivity | Hygroscopic |
| BRN | 1549242 |
Last Update：2024-04-09 15:16:16
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Uses and synthesis methods
introduction
BOC-glycine-N-hydroxysuccinimide ester is an amino acid intermediate, which can be prepared by one-step reaction of Boc-gly and lhosu. There are reports that it can be used to prepare endogenous collagen tripeptides.
Preparation
P> 110 moles of Boc-gly are treated with 115 moles of lhosu and 126 moles of dcc (the dosage of DCC is very particular in this reaction, but the reaction is incomplete and too much excess will generate larger and less polar impurities). in 220L acetone as solvent, the temperature is 13 ℃ for 3 hours to generate boc-gly.osu, dcu is filtered, the reaction solution is concentrated at 45 ℃, and a small amount of pet crystals are added, 105 moles of BOC-glycine-N-hydroxysuccinimide ester were obtained with 95% yield and HPLC>95%.Last Update：2024-04-09 21:01:54
tert-butylN-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbaMate - Reference Information
| Introduction | BOC-glycine-N-hydroxysuccinimide ester is an amino acid intermediate, which can be prepared by one-step reaction of Boc-gly and lhosu. There are reports that it can be used to prepare endogenous collagen tripeptides. |
| Uses | BOC-glycine-N-hydroxysuccinimide ester is an amino acid organic substance and can be used as a pharmaceutical intermediate. |
| preparation | 110 moles of Boc-gly are used with 115 moles of lhosu and 126 moles of dcc (the amount of DCC is very particular in this reaction, but the amount of reaction is incomplete and too much excess will generate larger and less polar impurities). in 220L acetone as solvent, the temperature is 13 ℃ for 3 hours, the boc-gly.osu was generated, dcu was filtered, the reaction solution was concentrated at 45 ℃, and a small amount of pet was added to crystallize to obtain 105 mol BOC-glycine-N-hydroxysuccinimide ester with a yield of 95% and HPLC>95%. |
Last Update：2024-04-09 21:01:54
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